Observations on Rate Theory for Rugged Energy Landscapes
نویسندگان
چکیده
منابع مشابه
Observations on rate theory for rugged energy landscapes.
The potential energy profile for many complex reactions of proteins, such as folding or allosteric conformational change, involves many different scales of molecular motion along the reaction coordinate. Although it is natural to model the dynamics of motion along such rugged energy landscapes as diffusional (the Smoluchowski equation; SE), problems arise because the frictional forces generated...
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Understanding the static and even more the dynamical behavior of complex physical systems is one of the most challenging problems of current research in physics, chemistry and biology. Paradigmatic examples of condensed matter physics are spin glasses and structural glasses. More recently, in life sciences, the rapid advances in computational biology have added the exploration of the properties...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.108.136358